& Annie: There are great mysteries out there. Strange and magical, hidden in codes. Did you ever wonder... if you knew those codes, could you change your future?
& — So I have to ask, Dr. King. What’s the story with the clock there?
Mary-Claire King: The clock is marked at every 12 minutes. That’s how often a woman will die of breast cancer in this country.
— Well, that’s—
Mary-Claire King: One in nine. Two million over the next 20 years.
— Potentially, but—
Mary-Claire King: Maybe your wife... Your daughter...
& Mary-Claire King: To prove it, we have to do four things. Sarah? First?
Sarah: Find a group of women who have breast cancer, and from within that group, women who have relatives who have breast cancer.
Mary-Claire King: Second?
Sarah: We then need to find a way to track the inheritance of our breast cancer gene from generation to generation.
Mary-Claire King: Third?
Sarah: Even if we manage to map the gene to a specific chromosome, we then need to isolate and sequence it to find the mutation, which will take years. And then, uh— then we find out if it repeats in the relatives. And if it does, then that is our link.
Mary-Claire King: Fourth?
Sarah: Fourth and, realistically, maybe the most difficult. We then need to figure out why a mutation in a single gene could lead to breast cancer in so many women.
Mary-Claire King: Wonderful. See you first thing.
& Paul: Look at me. I’m a Canadian pool man. I’m like one of those oxy— oxy—
Annie: Morons.
Paul: Morons!
& Annie: Yeah, yeah. I know. But we were young, and we had lots of time on our hands.
& Paul: He’s— He’s good-looking. For a baby, you know. In an ugly kind of way. ... He’s got bass player hands. ... I mean, I’m not saying that, you know, babies are ugly. They just got that kind of ugly baby thing going.
& Tom: I don’t know about genetics. I know about computers. You see, I make these cards, and then I load them into the front of the computer, along with everyone else’s, and then, usually the next day sometime, depending on how many other people are using the computer, maybe a few days later, I get this printout. And there you go.
Mary-Claire King: And for the amount of data we’re going to have, how fast?
Tom: The university’s mainframe computer weighs two and a half tons. It’s capable of storing 700 kilobytes of data.
Mary-Claire King: I’m sorry. How long?
Tom: Once we get the data, make a program and then load it... Ten years?
& Dr. Gold: We don’t know what happened to your family. We may never know.
Annie: ... My mom used to wrap hot dogs in bacon, and then deep-fried them.
& Louise: It’s not too late to reach out to him and to let him know how you feel.
Annie: What, like a blow job?
Louise: Yeah, that’s exactly what I mean.
& Annie: Is this a doctorly hug?
& Annie: Love is like DNA. We can’t know its predispositions.
--
On the IMDb
& — So I have to ask, Dr. King. What’s the story with the clock there?
Mary-Claire King: The clock is marked at every 12 minutes. That’s how often a woman will die of breast cancer in this country.
— Well, that’s—
Mary-Claire King: One in nine. Two million over the next 20 years.
— Potentially, but—
Mary-Claire King: Maybe your wife... Your daughter...
& Mary-Claire King: To prove it, we have to do four things. Sarah? First?
Sarah: Find a group of women who have breast cancer, and from within that group, women who have relatives who have breast cancer.
Mary-Claire King: Second?
Sarah: We then need to find a way to track the inheritance of our breast cancer gene from generation to generation.
Mary-Claire King: Third?
Sarah: Even if we manage to map the gene to a specific chromosome, we then need to isolate and sequence it to find the mutation, which will take years. And then, uh— then we find out if it repeats in the relatives. And if it does, then that is our link.
Mary-Claire King: Fourth?
Sarah: Fourth and, realistically, maybe the most difficult. We then need to figure out why a mutation in a single gene could lead to breast cancer in so many women.
Mary-Claire King: Wonderful. See you first thing.
& Paul: Look at me. I’m a Canadian pool man. I’m like one of those oxy— oxy—
Annie: Morons.
Paul: Morons!
& Annie: Yeah, yeah. I know. But we were young, and we had lots of time on our hands.
& Paul: He’s— He’s good-looking. For a baby, you know. In an ugly kind of way. ... He’s got bass player hands. ... I mean, I’m not saying that, you know, babies are ugly. They just got that kind of ugly baby thing going.
& Tom: I don’t know about genetics. I know about computers. You see, I make these cards, and then I load them into the front of the computer, along with everyone else’s, and then, usually the next day sometime, depending on how many other people are using the computer, maybe a few days later, I get this printout. And there you go.
Mary-Claire King: And for the amount of data we’re going to have, how fast?
Tom: The university’s mainframe computer weighs two and a half tons. It’s capable of storing 700 kilobytes of data.
Mary-Claire King: I’m sorry. How long?
Tom: Once we get the data, make a program and then load it... Ten years?
& Dr. Gold: We don’t know what happened to your family. We may never know.
Annie: ... My mom used to wrap hot dogs in bacon, and then deep-fried them.
& Louise: It’s not too late to reach out to him and to let him know how you feel.
Annie: What, like a blow job?
Louise: Yeah, that’s exactly what I mean.
& Annie: Is this a doctorly hug?
& Annie: Love is like DNA. We can’t know its predispositions.
--
On the IMDb
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